Secreted CXCL12 (SDF-1) forms dimers under physiological conditions
نویسندگان
چکیده
منابع مشابه
CXCL12/SDF-1 and CXCR4
Chemokines are a large family of structurally related chemoattractive cytokines, which have four conserved cysteines forming two disulfide bonds, and act through seven-transmembranespanning receptors coupled to heterotrimeric GTP-binding proteins (G-protein-coupled receptors). Chemokines were thought to be signaling molecules that attract leukocytes to sites of inflammation; however, CXC chemok...
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Chemokines, small proinflammatory chemoattractant cytokines that bind to specific G-protein-coupled seven-span transmembrane receptors, are major regulators of cell trafficking and adhesion. The chemokine CXCL12 [stromal cell-derived factor-1 (SDF-1)] binds primarily to CXC receptor 4 (CXCR4; CD184). The binding of CXCL12 to CXCR4 induces intracellular signaling through several divergent pathwa...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 2012
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj20111341